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Czech National Team
Projekty
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Právě je neděle, 8.září 2024, 11:24 hod.
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Seznam projektů |
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base R16 Megaprime  |
grcpool.5, a member of the team Gridcoin found a megaprime for base R16.
The prime 21555*2^7364128-1 has 2.216.828 digits and entered the T5k PrimePages.
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| Processing of the square # 45 completed |
Dear participants, processing of the square # 45 is fully completed! The square:
0 1 2 3 4 5 6 7 8 9 A B
1 2 0 4 5 3 8 9 A B 6 7
2 0 1 5 3 4 A B 6 7 8 9
8 A 6 7 9 B 0 4 1 5 2 3
A 6 8 9 B 7 1 5 2 3 0 4
9 B 7 6 8 A 4 0 5 1 3 2
5 3 4 0 1 2 9 8 B A 7 6
4 5 3 2 0 1 7 6 9 8 B A
B 7 9 8 A 6 5 1 3 2 4 0
6 8 A B 7 9 2 3 0 4 1 5
7 9 B A 6 8 3 2 4 0 5 1
3 4 5 1 2 0 B A 7 6 9 8
has 491608552 orthogonal mates which puts it on the 36th place of the rating which include now 5780 positions.
Thank you for project attention, support and donation of CPU time!
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| Processing of the square # 44 completed |
Dear participants, processing of the square # 44 is fully completed! The square:
0 1 2 3 4 5 6 7 8 9 A B
1 2 3 4 9 6 7 A B 0 8 5
9 0 1 2 3 B 5 6 A 4 7 8
8 B 5 6 7 2 3 4 0 A 9 1
6 7 A 8 B 9 0 1 3 5 2 4
5 6 7 A 8 4 9 0 2 B 1 3
2 3 4 9 0 7 A 8 5 1 B 6
4 9 0 1 2 8 B 5 7 3 6 A
A 8 B 5 6 1 2 3 9 7 4 0
B 5 6 7 A 3 4 9 1 8 0 2
7 A 8 B 5 0 1 2 4 6 3 9
3 4 9 0 1 A 8 B 6 2 5 7
has 541829049 orthogonal mates which puts it on the 27th place of the rating.
Thank you for project attention, support and donation of CPU time!
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| Processing of the square # 43 completed |
Dear participants, processing of the square # 43 is fully completed! The square:
0 1 2 3 4 5 6 7 8 9 A B
1 2 0 4 5 3 8 6 7 B 9 A
3 4 5 0 1 2 A B 9 8 6 7
7 6 8 B A 9 2 1 0 3 5 4
6 8 7 A 9 B 0 2 1 4 3 5
B A 9 7 6 8 5 4 3 0 2 1
8 7 6 9 B A 1 0 2 5 4 3
9 B A 8 7 6 4 3 5 2 1 0
A 9 B 6 8 7 3 5 4 1 0 2
2 0 1 5 3 4 7 8 6 A B 9
5 3 4 2 0 1 B 9 A 6 7 8
4 5 3 1 2 0 9 A B 7 8 6
has 507261172 orthogonal mates which puts it on the 34th place of the rating.
Thank you for project attention, support and donation of CPU time!
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| Processing of the square # 42 completed |
Dear participants, processing of the square # 42 is fully completed! The square:
0 1 2 3 4 5 6 7 8 9 A B
1 2 0 4 9 8 B 6 A 3 5 7
3 4 9 0 1 6 5 A B 2 7 8
A 5 8 7 6 0 3 9 1 B 2 4
6 B 7 5 8 4 1 0 9 A 3 2
5 8 A 6 B 1 4 3 2 7 0 9
9 3 4 2 0 7 A 8 6 1 B 5
2 0 1 9 3 A 7 B 5 4 8 6
7 6 B A 5 3 0 2 4 8 9 1
B 7 6 8 A 9 2 1 3 5 4 0
4 9 3 1 2 B 8 5 7 0 6 A
8 A 5 B 7 2 9 4 0 6 1 3
has 508625638 orthogonal mates which puts it on the 33th place of the rating.
Thank you for project attention, support and donation of CPU time!
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| Processing of the square # 41 completed |
Dear participants, processing of the square # 41 is fully completed! The square:
0 1 2 3 4 5 6 7 8 9 A B
1 2 0 4 5 3 8 6 7 B 9 A
2 0 1 5 3 4 7 8 6 A B 9
8 7 6 9 B A 1 0 2 5 4 3
7 6 8 B A 9 2 1 0 3 5 4
9 B A 6 8 7 4 3 5 1 0 2
5 3 4 1 2 0 B 9 A 7 8 6
A 9 B 7 6 8 3 5 4 0 2 1
B A 9 8 7 6 5 4 3 2 1 0
6 8 7 A 9 B 0 2 1 4 3 5
4 5 3 0 1 2 9 A B 8 6 7
3 4 5 2 0 1 A B 9 6 7 8
has 524388782 orthogonal mates which puts it on the 32th place of the rating.
Thank you for project attention, support and donation of CPU time!
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| PRS Found! |
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On 27 July 2024, 09:18:10 UTC, PrimeGrid's Primorial Prime Search found the Primorial Prime:
4328927#+1
The prime is 1,878,843 digits long and will enter “The Largest Known Primes Database” ranked 1st for Primorial primes and 373rd overall.
The discovery was made by Kai Presler (Aperture_Science_Innovators) of Antarctica using an Intel(R) Xeon(R) CPU E7-8890 v4 @ 2.20GHz with 256GB RAM, running Linux Mint 21.1. This computer took about 6 hours, 53 minutes to complete the probable prime (PRP) test using PRST. Kai Presler is a member of the [H]ard|OCP team.
The PRP was confirmed prime on 29 July 2024 by an AMD Ryzen 9 7950X3D @ 4.20GHz with 128GB RAM, running Debian 12.5. This computer took about 2 days, 3 hours, 38 minutes to complete the primality test using PFGW with 4 threads.
For more details, please see the official announcement.
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| Rosetta version 4.29 released for testing |
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The Rosetta application has been updated to include fixes to the core algorithm for protein modeling. Due to how the algorithm interacts internally, we will leave graphics disabled for this version. Please report any issues in the discussion thread here: https://ralph.bakerlab.org/forum_thread.php?id=944
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| BOINC server migration and upgrade |
The project will be offline starting at 3:00 PM UTC on August 9th in order to migrate and update the BOINC server.
The operation could last until August 12th.
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| A mid-summer ping |
Just a ping to state that the project is alive and running.
The last year I was way too optimistic in forecasting that a big new experiment would have started soon. I was wrong, in the last months just a handful of workunits were distributed. Anyway, even in this strange and hot summer, the scientists are working, and the project is making progress, although we cannot say when new job will be available.
BTW, if you want to check something we did recently, although still in beta stage, just go to https://onegene-causality-weaver.disi.unitn.it/
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| Project progress and summer period // Avance del proyecto y período estival |
Dear volunteers,
First of all, please excuse me because I wanted to send this message a week ago, but I was not able to do so. As you have seen these days, just like last year, we are entering the summer period, and the rate of sending simulations will be affected. We hope that it does not stop completely, but the sent tasks will be reduced.
I take this opportunity to update the results of the last months: you have been optimizing one of the most used human ventricle models: the O'Hara and Rudy model. We have tested several optimization configurations and have obtained a new adjustment for the model that improves its behavior in relation to a large number of markers reported in the scientific literature. There is still a configurations that has not been finished, but we are already beginning to prepare a scientific publication that summarizes our results. As soon as it is finished and published (it is a long process), we will share it with you and explain it.
In the coming months we will begin to optimize a version of this widely used model, which is the basis of a new model we are developing to study heart failure. We will take advantage of this change in model to automate some things, so the slow pace of summer may be a little longer at the beginning of the school year, but with the objective that the pace will not slow down afterwards.
Thank you all very much for your understanding, and this afternoon, new tasks.
Best regards,
Jesus.
======================================================================
Estimados voluntarios:
En primer lugar, disculpadme porque este mensaje quería haberlo mandado hace una semana, y no pude hacerlo. Como habéis comprobado estos días, al igual que el año pasado, entramos en el período estival, y el ritmo de envío de simulaciones se verá afectado. Esperemos que no se detenga del todo pero se reducirán las tareas que enviaremos.
Aprovecho para actualizaros que en los últimos meses, habéis estado optimizando uno de los modelos de ventrículo humano más utilizados: el modelo de O'Hara y Rudy. Hemos probado varias configuraciones de la optimización y hemos obtenido un nuevo ajuste del modelo que mejora el comportamiento del mismo con relación a una gran cantidad de marcadores reportados en la literatura científica. Queda un poco para que termine una de las configuraciones, pero estamos ya comenzando a preparar una publicación científica que resuma nuestros resultados. Tan pronto como esté terminada y publicada (es un proceso largo), os la compartiremos y explicaremos.
En los próximos meses comenzaremos a optimizar una versión de este modelo que se usa mucho y que es la base de un nuevo modelo que estamos desarrollando para estudiar la insuficiencia cardiaca. Aprovecharemos este cambio de modelo para automatizar algunas cosas, así que igual el ritmo lento de verano se alarga un poco al comienzo de curso, pero con la idea de que después no baje el ritmo.
Muchas gracias a todos por la comprensión, y esta tarde, tareas nuevas.
Un saludo,
Jesús.
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| Aliquot sequence 318330 has terminated!!! |
Aliquot sequence 318330 has terminated!!!
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| Shutdown on 19 July (Friday afternoon) |
Dear All,
This email is to inform you of a planned power and network outage in the whole CAMK building scheduled for Friday, July 19th, after 4 pm (CET). The outage is necessary to connect photovoltaic component to our power circuits.
We plan to minimize the downtime, but we cannot make any promises. We were told that all critical works should be finalized on the same day, unfortunately, it may take twice the time that our UPS can support.
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| BOINC Games sprint 07/15/2024 08:00 (UTC) - 07/18/2024 08:00 (UTC) |
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If you are a new member create an account over the website.
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| Trial Factoring 75-76bit range started |
The next batch of 50k tests is uploading.
The runtime is now ~2h40min on a RX5500 XT and decreasing on higher ranges.
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| Target # 23: Ebola GP1 |
Dear participants,
as target # 22 is almost finished, we are glad to introduce the next target. Most of you have voted for Ebolavirus glycoprotein (GP) (174 out of 425 votes, wow!)
The Ebola virus is a highly virulent pathogen responsible for causing Ebola hemorrhagic fever, a severe and often fatal disease. A key factor in the virus's ability to infect host cells and cause disease is its surface glycoprotein (GP), making it an attractive target for antiviral drug development. The Ebola GP is a trimeric protein composed of two subunits per monomer: GP1, responsible for receptor binding, and GP2, which mediates fusion between the viral and host cell membranes. Initially synthesized as a precursor protein, the GP is cleaved by host proteases (furin, cathepsin) into its functional subunits, a process essential for its role in mediating viral entry. The GP facilitates the virus's attachment to the host cell surface, followed by conformational changes that enable membrane fusion, allowing the virus to enter the host cell (to the host endosomal Niemann-Pick C1 (NPC1) receptor or via direct membrane binding; Vaknin et al.; ACS Infect. Dis. 2024, 10, 5, 1590–1601).
Targeting the GP for drug development is advantageous due to its essential role in viral infection, its highly conserved structure among different Ebola virus strains, and the availability of specific binding cavities that can accommodate small-molecule inhibitors. Structural studies using techniques such as X-ray crystallography have identified these binding cavities and elucidated the GP's conformation in both its free and inhibited states. These insights enable the design of drugs that can specifically bind to and inhibit the GP by stabilizing it in its pre-fusion conformation or interfering with its cleavage, thereby preventing the necessary conformational changes for membrane fusion. We will employ high-resolution structures to conduct virtual screening experiments coupled to molecular dynamics simulations to ultimately identify potential GP inhibitors/modulators.
Promising compounds identified through these computational methods will hopefully undergo further validation using biochemical assays, pseudovirus entry assays, and structural analyses to confirm their inhibitory activity. Targeting the GP offers specificity, as it minimizes off-target effects on host cells and reduces the likelihood of resistance development. Moreover, due to the conserved nature of the GP, drugs targeting it could be effective against multiple Ebola virus strains and variants.
We hope that our computations will contribute to the fight against Ebola!
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| Aliquot sequence 2896896 has terminated!!! |
Aliquot sequence 2896896 has terminated!!!
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| New batch going out to volunteer's machines: STORMS, investigating how low-pressure systems may change in the future |
Project: Quantifying controls on the intensity, variability and impacts of extreme European STORMS
by Clément Bouvier and Victoria Sinclair (University of Helsinki)
Throughout the year, low-pressure systems regularly move across Europe, usually from west to east, bringing cloud, rain and windy weather. Sometimes these weather systems can become very intense, and the winds and rain associated with them can cause damage to buildings and infrastructure, flooding, and can disrupt electricity supply and travel. Although the short-term weather forecasts of these storms are now quite accurate, it still remains uncertain how these storms, and their impacts, are likely to change in the future as our climate changes. Some of this uncertainty is because our understanding of what controls the strength and impacts of these storms is incomplete.
The aim of this project is to understand what controls the strength and structure of these low-pressure systems. We will quantify how the atmospheric state that the low-pressure systems develop in affects the strength and structure of these low-pressure systems. This atmospheric state can be described by various parameters, for example, the mean temperature, moisture content, and upper-level wind speeds (i.e. the strength and width of the jet stream). Since there are lots of different parameters we want to study (not just the ones described above), we want to do lots of experiments in a high controlled manner. Therefore, we will run a large ensemble of simulations of idealised low-pressure systems using the numerical weather prediction model OpenIFS. Although the simulations are idealised, the weather systems that develop look very like real weather systems that we observed in reality. Each ensemble member differs in its initial atmospheric state, and we choose these initial states to cover everything from the current climate to past pre-industrial climates to the most extreme future climate projections. This is exciting because although idealised simulations of low-pressure systems have been performed before, this is the first time that such an extensive exploration of the parameter space will be conducted.
Once we have the results from the large ensemble, we will calculate different measures of the strength of the storms and then use machine learning techniques to see how these relate to the initial states. Our results will hopefully increase in confidence in how these storms and their impacts will change in the future.
Technical information:
Run time: between 8 and 9 hours for 1 workunit (1 core, Xeon Gold 6230)
Number of files: 480 files
Maximum size of individual files: 1.3MB for 2D fields output files, 13.3MB for spectral output files, 7.1MB for 3D fields output files
Total disk load: 2.0GB
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| The server / project is restarted now |
There is a slow progress from rehab but not happy with the results yet. All of the recovering is very slowly with restrictions.
The RAM was tested in the first run and looking ok.
I will test some work too.
I really missed the last pentathlon. Hoping to finish the TF range of GIMPS work too.
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| Electrical work 3 |
I just being informed now that tomorrow 29/05/2024 in my area there will be another electrical power off from 9:00 to 16:00!!!!
This means that battery power supply cannot handle 7 hours of power failure, so I need to program that the server shot down automatically before 9:00 to preserve it.
It need to be manually power on and this could be done at 19:00.
Sorry for the problems.
Thanks
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