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Právě je neděle, 25.září 2016, 22:47 hod.
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CSG 2016-09-25 09:00:40
[dna] new DNA@Home runs up and going Nové okno
Then you're missing the context.
...

Hehe, no, I simply interpreted it a bit on my own view to fit my need. ;-)
but are choosing not to because Travis doesn't jump at your command. There must be a lot of live, active projects that you refuse to run.

LOL, a funny nice jump to conclusions and a perfect reversion of what I really said.
;-)

 
SRBase 2016-09-24 11:59:36
validator changes (done) Nové okno
Later today I will do some changes on the validators. There is one fix and another change to mark some results invalid due OC issues.

 
MilkyWay 2016-09-24 06:54:20
MilkyWay@home Down Nové okno
Hey everyone,

Looks like the database has been down for a little over 30 hours and the boinc daemons are still struggling. Not entirely sure what happened, but I'm working through trying to fix it. I apologize for the slow progress being made, all of the major MilkyWay@home scientists, including myself are visiting collaborators in Canada and have been quite busy. I will try to get things fixed over night.

Jake

[edit]

Everything seems to be working now. I'll check back in the morning to make sure everything is still working.

[/edit]

 
Rosetta 2016-09-23 09:00:00
Project News Sep 23, 2016 Nové okno
Some good news! We recently published an article in Nature titled "Accurate de novo design of hyperstable constrained peptides". We would like to thank all Rosetta@Home participants for their help with this work. In the paper, we present computational methods for designing small stapled peptides with exceptional stabilities. These methods and designed peptides provide a platform for rational design of new peptide-based therapeutics. Constrained (stapled) peptides combine the stability of conventional small-molecule drugs with the selectivity and potency of antibody therapeutics. The ability to precisely design these peptides in custom shapes and sizes opens up possibilities for "on-demand" design of peptide-based therapeutics. Other developments described in the paper: We can now accurately design 18-47 amino acid peptides that incorporate multiple cross-links. We can now design peptides that incorporate unnatural amino acids. Specifically, we designed peptides with a mix of natural L-amino amino acids and D-amino acids (mirror images of L-amino acids). D-amino acids tend to provide better protease resistance and lower immunogenicity; both of which are desired properties in a therapeutic peptide. Unnatural amino acids also let us sample much more diverse shapes and functions. We can now design peptides that are cyclized via a peptide bond between their N- and C-terminus. Cyclic peptides provide increased resistance against exopeptidases as they have no free ends, and thus are ideal candidates for engineering peptide therapeutics. We are now working to use these computational methods for designing peptides that target therapeutically relevant targets, such as, enzymes that impart antibiotic resistance in pathogenic bacteria. Structure prediction runs on Rosetta@Home for these designed peptide models played a key role in selection of good designs that were experimentally synthesized and characterized. Thank you all for your help in making this work possible! -- Gaurav B. For more information: IPD News. Nature paper "Accurate de novo design of hyperstable constrained peptides". Nature review "The coming of age of de novo protein design".

 
Cosmology 2016-09-22 17:19:08
Some security and cosmetic upgades Nové okno
We have added the option to access the C@H website more securely via "https", if you'd like to do so, you can update your bookmarks to use https://www.cosmologyathome.org. For now this remains purely optional (for example, if you don't know what https is, you can ignore this). At some point in the future, we will likely move to requiring this, but we'll give warning and post more details then.

Also, I've fixed a number of minor cosmic things about the site, most notably 1) the BBCode buttons when posting to the forums now work 2) a number of pages which were rendered too wide should now correctly fit the screen. If, as you're using the site, you find any other glitches, please don't hesitate to take a screenshot and post on the forums so we can fix things! Thanks all! (Edit: ha, oops meant to say *cosmetic* things above, although I'll leave in the somewhat appropriate typo)

 
Virtual LHC 2016-09-22 11:30:11
SSL connection option Nové okno
For those with BOINC clients above version 7.2, there is now an option to connect with SSL on the URL:

https://lhcathome.cern.ch/vLHCathome/

This server runs a web-front end and scheduler for this project. To use it, please detach fron the project, and re-attach using the new HTTPS URL.

The other project daemons still run on the same server as before. The old server and URL will remain in place until further notice.

So far our tests of this distributed server setup works fine, and we would appreciate feedback in case of problems.

 
PrimeGrid 2016-09-20 19:39:19
The Hunt for AP27 Nové okno
PrimeGrid has begun searching for an AP27 (arithmetic progression of primes of 27 terms). Six years ago, we found the first known AP26. Help us search for an AP27! Details and discussions can be found on the forums.

 
PrimeGrid 2016-09-20 14:47:37
World Record Twin Primes Found! Nové okno
On 14 September 2016 04:24:46 UTC, PrimeGrid’s Sophie Germain Prime Search found World Record twin primes: 2996863034895*2^1290000±1 The twin primes are 388,342 digits long, eclipsing the previous record of 200,700 digits. They will enter Chris Caldwell's The Largest Known Primes Database ranked 1st for twins, and each entered individually ranked 4180th overall. The discovery was made by Tom Greer (tng*) of the United States using an Intel(R) Xeon(R) CPU E5-2623 v3 @ 3GHz with 32 GB RAM running Windows 10 Professional. This computer, using LLR, took approximately 23 minutes to complete the primality tests of both primes. Tom is a member of the Sicituradastra. team. The prime was verified on 15 September 2016 01:32:51 UTC, by Don Palmer (Don Palmer) of Canada using an Intel(R) Core(TM)2 Duo CPU E7600 @ 3.06GHz with 4 GB RAM running OS X 10.11.6. This computer, using LLR, took approximately 1 hour 37 minutes to complete the primality tests of both primes. Don is a member of the Team Canada team. For more details, please see the official announcement.

 
MilkyWay 2016-09-19 21:36:22
MilkyWay@home Version 1.38 Released Nové okno
Hello Everyone,

I just released the newest version of the MilkyWay@home application (1.38). The only major change to this version is an inclusion of the newest BOINC libraries in an attempt to improve compatibility with the new graphics cards.

Mac users will still receive the 1.36 application version for the time being while we work on securing a new Mac computer to build and test on for the future.

If you notice any issues with this application please post them here.

Happy Crunching,

Jake

 
WEP-M+2 2016-09-19 12:53:07
12-digit factor of P2203 has now been found by the project... Nové okno
...95754 times

 
SRBase 2016-09-18 11:47:36
another R430 Megaprime Nové okno
On 04th of August, Odicin, a member of the team BOINC Confederation has found a megaprime 39653*430^460397-1 for base R430. The prime has 1.212.446 digits and entered the TOP5000 in Chris Caldwell's The Largest Known Primes Database. There are now 13k left.

Well done!

 
SRBase 2016-09-17 18:59:41
base R72 proven Nové okno
On 30th of August, Ralfy, a member of the BOINC Confederation found the last prime for base R72.
The prime 4*72^1119849-1 has 2079933 digits and entered the TOP5000 in Chris Caldwell's The Largest Known Primes Database. This is the largest prime ever found by SRBase and the 2nd largest prime for the Mersenne CRUS project.

Well done!

 
SAT 2016-09-16 10:27:00
No new tasks temporarily Nové okno
Work generetor was temporarily stopped. We are going to move the project to a new sever approximately in November, so we need all tasks to be processed.

Генератор заданий временно остановлен. Мы собираемся перенести проект на новый сервер в ноябре, поэтому нам нужно, чтобы все задания были обработаны.

 
NFS 2016-09-15 20:51:54
2,1954M, 2,1982M, 2,1009+, 2,1019+, XYYXF 139,122, and XYYXF 147,136 factored Nové okno
We have completed 2,1954M, 2,1982M, 2,1009+, and 2,1019+ from the Cunningham Project, and 139,122 and 147,136 from the XYYXF project. Details of all of these factorizations are available on the Status of Numbers page. Let's keep it up!
[Edited to add 2,1019+]

 
SAT 2016-09-15 11:11:00
New solutions found Nové okno
4 new pairs of MODLS of order 10 were found in the current experiment (# 57-60 in the list of solutions found).

4 новые пары ОДЛК порядка 10 были найдены в текущем эксперименте (№ 57-60 в списке найденных решений).

 
Universe 2016-09-13 18:17:27
UV and BHspin2 tasks Nové okno
Regarding to latest problems with tasks submissions to your computers we plan to make some maintenance work on our server and results analyse machine at the end of this week or start of next one.
The server will be stopped for about 6 hours but I will publish info when this happens before we start.

 
ATLAS 2016-09-13 10:09:56
Changes to the multicore app configuration Nové okno
After analysis of results from the multicore app (see this thread) we have made the following changes

- Minimum VirtualBox version required is 5.0.0
- Maximum cores reduced from 12 to 8 (this can be overridden in app_config.xml but we have seen severe performance issues above 8 cores)
- Enforced that hardware acceleration is enabled on the host. This should stop the -148 ERR_EXEC errors because WU will not be sent to these hosts.

Please continue to provide your feedback on changes we make.

 
PrimeGrid 2016-09-13 00:45:21
PRPNet September Challenge Nové okno
Libra Equinox Challenge Announced is a PRPNet challenge at the 27 prime search project from the 20th till 27th of September. Leading edge of the search now up to 6,062,752 on both the plus and minus sides. Goal will be to get to 6.3M. More about the 27121 prime search can be found here. News and infos about the PRPNet client can be found here. To take part, you have to activate the following lines in prpclient.ini: server=27:100:1:prpnet.primegrid.com:12006 Stats will be available at the well known place here. All previous PRPNet challenge stats can be found here. Discussion and more information can be found here: 2016 PRPNet September Challenge. Good luck!

 
PrimeGrid 2016-09-12 15:02:29
Double checking is now required for all tasks Nové okno
PrimeGrid has turned on double checking for the SGS-LLR, PPSE-LLR, and PPS-LLR sub-projects. All of our other projects already had double checking enabled. More details and discussion can be found here: http://www.primegrid.com/forum_thread.php?id=7007

 
Rosetta 2016-09-12 09:00:00
Project News Sep 12, 2016 Nové okno
In the last few weeks our project has experienced significant issues resulting in slower than usual work unit distribution, result processing, and credit granting. The cause of this was due to the increasingly large number of new hosts causing our database server to become very sluggish and eventually run out of disk space. Our short term solution was to reconfigure and optimize the project configuration and existing database server, purge old data quicker than usual, and temporarily stop resource intense database queries. This recovery mode will continue until the project stabilizes which may take a few days to a week. An interim solution will be to temporarily upgrade our database server and thanks to our sys admins, we already have a machine ready to go that has plenty of disk space and double the memory. The upgrade will require a day of downtime which is planned to happen early this week. The long term solution will be a complete system hardware upgrade to all our servers. The BOINC server software will also be upgraded. We are in the process of ordering these machines and hope to have them running within the next few months. The project is somewhat stable now and clients should be getting work as usual. However, result processing and credit granting may still be slow and our status information/page may not be up to date as we are in recovery mode and our servers continue to catch up on things. Work history will also be shortened to temporarily save space. We expect things to be back to normal in a few days to a week. Sorry for any inconvenience and thank you for your continued contributions!


 Další

Thanks to David Vignoni for graphics and inspiration.


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